Lawsone, Juglone, and β-Lapachone Derivatives with Enhanced Mitochondrial-Based Toxicity
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چکیده
منابع مشابه
zinc(II) with lawsone, juglone and naphthazarin
The complexation equi li bria of zinc(lI ) wi th 2-hydroxy-IAnaphthoquinone. 5-hydroxyIA-naphthoquinone and 5.8-dihydroxyIA-naphthoquinone have been studied spectrophotometri call y as a function of pH in 50~ (1'/1') ethanol-water medium at 25°C and an ionic strength of 0.1 M NaCI04 . The spectral study of the complexati on reactions has been carried out in solutions contain ing equimolar conce...
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Naphthoquinones are secondary metabolites widely distributed in nature and produced by bacteria, fungi and higher plants. Their biological activity may result from induction of oxidative stress, caused by redox cycling or direct interaction with cellular macromolecules, in which quinones act as electrophiles. The redox homeostasis is known as one of factors involved in auxin-mediated plant grow...
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Anthelmintics used for intestinal helminthiasis treatment are generally effective; however, their effectiveness in tissue parasitosis (i.e. visceral toxocariasis) is moderate. The aim of this study was to evaluate the in vitro activity of lapachol, β-lapachone and phenazines in relation to the viability of Toxocara canis larvae. A concentration of 2 mg/mL (in duplicate) of the compounds was tes...
متن کاملAntibacterial and antifungal activity of lawsone and novel naphthoquinone derivatives.
INTRODUCTION Naphthoquinone derivatives are under investigation as potential therapeutic agents. The antibacterial and antifungal activity of lawsone and of some novel naphthoquinone derivatives was assessed in vitro. METHODS The antimicrobial activity was determined using diffusion disk and the broth microdilution methods against seven bacteria and three Candida species, according to recomme...
متن کاملProdrug strategy to achieve lyophilizable, high drug loading micelle formulations through diester derivatives of β-Lapachone.
β-Lap prodrug micelle strategy improves the formulation properties of β-lap therapeutics. The resulting micelles yield apparent high β-lap solubility (>7 mg mL(-1) ), physical stability, and ability to reconstitute after lyophilization. In the presence of esterase, β-lap prodrugs are efficiently converted into parent drug (i.e., β-lap), resulting in NQO1-dependent lethality of NSCLC cells.
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ژورنال
عنوان ژورنال: ACS Chemical Biology
سال: 2018
ISSN: 1554-8929,1554-8937
DOI: 10.1021/acschembio.8b00306